GW 9662

Grouped product items
SizePrice Qty
10mg
$75.00
50mg
$310.00
Catalog Number : 2292528

description

GW 9662 is an irreversible selective antagonist of PPARgamma, which regulates fatty acid storage and glucose metabolism. It is a more potent alternative to the BADGE molecule and is reported to have anticancer properties and to be useful in blocking the differentiation of monocytes to osteoclasts.
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Additional Information

Applications:
FA
Synonyms:
2-Chloro-5-nitrobenzanilide, GW9662, GW-9662
Formulation:
Crystalline solid
Chemical Name:
2-chloro-5-nitro-N-phenylbenzamide
Molecular Formula:

C13H9ClN2O3

Molecular Weight:
276.7
CAS Number
22978-25-2
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Seargent, J. M., Yates, E. A., & Gill, J. H. (2004). GW9662, a potent antagonist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation. British journal of pharmacology143(8), 933-937.

Collino, M., Patel, N. S., Lawrence, K. M., Collin, M., Latchman, D. S., Yaqoob, M. M., & Thiemermann, C. (2005). The selective PPARγ antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney international68(2), 529-536.

Wojtowicz, A. K., Szychowski, K. A., & Kajta, M. (2014). PPAR-γ agonist GW1929 but not antagonist GW9662 reduces TBBPA-induced neurotoxicity in primary neocortical cells. Neurotoxicity research25(3), 311-322.

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