Go 6983
Catalog Number : 1331975
description
Go 6983 is a broad fast-acting inhibitor of various isoforms of protein kinase C. It can be used to inhibit differentiation and maintain the pluripotency of embryonic stem cells and enhance stem cell viability and growth. Go 6983 is also reported to exert cardio protective effects in myocardial ischemia and inhibited intracellular Ca accumulation.
Additional Information
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Applications:
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FA
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Synonyms:
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Gö6983, Gö 6983, 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide
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Formulation:
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Crystalline solid
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Chemical Name:
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3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
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Molecular Formula:
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C26H26N4O3 |
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Molecular Weight: |
442.5
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CAS Number
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133053-19-7
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Peterman, E. E., & Taormina, P. II, Harvey, M., and Young, LH 2004. Go 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J. Cardiovasc. Pharmacol, 43, 645-656. Young, L. H., Balin, B. J., & Weis, M. T. (2005). Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.Cardiovascular drug reviews, 23(3), 255-272. Gschwendt, M., Dieterich, S., Rennecke, J., Kittstein, W., Mueller, H. J., & Johannes, F. J. (1996). Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes. FEBS letters, 392(2), 77-80.
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