Garcinol

Grouped product items
SizePrice Qty
10mg
$90.00
25mg
$210.00
Catalog Number : 7883034

description

Garcinol is a polyisoprenylated benzophenone derivative and a potent inhibitor of histone acetyltransferases (HATs) PCAF and p300. It has been used to inhibit the growth of cancer cell lines and to promote ex vivo expansion of human stem cells. Garcinol also exhibits antioxidative and chelating activity and is reported to induce apoptosis in HeLa cells by downregulating their global gene expression.
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Additional Information

Applications:
FA
Synonyms:
Camboginol, CCRIS 9029, CHEMBL502489
Formulation:
Crystalline solid
Chemical Name:
(1S,3E,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxymethylidene]-6,6-dimethyl-5,7-bis(3-methylbut-2-enyl)-1-[(2S)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione
Molecular Formula:

C38H50O6

Molecular Weight:
602.8
CAS Number
78824-30-3
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Yamaguchi, F., Ariga, T., Yoshimura, Y., & Nakazawa, H. (2000). Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. Journal of Agricultural and Food Chemistry48(2), 180-185.

Balasubramanyam, K., Altaf, M., Varier, R. A., Swaminathan, V., Ravindran, A., Sadhale, P. P., & Kundu, T. K. (2004). Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. Journal of Biological Chemistry,279(32), 33716-33726.

Pan, M. H., Chang, W. L., Lin-Shiau, S. Y., Ho, C. T., & Lin, J. K. (2001). Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. Journal of agricultural and food chemistry49(3), 1464-1474.

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