EX 527

Grouped product items
Size	Price	Qty
5mg	$30.00
10mg	$85.00

Catalog Number : 4989833

description

EX 527 is a selective inhibitor of NAD-dependent deacetylase sirtuin-1 (SIRT1) to the exclusion of histone deacetylases (HDACs) and other sirtuins. It is reported that inhibiting SIRT1 is associated with increasing insulin sensitivity and effecting other metabolic regulatory functions. EX 527 was used to determine that the inactivation of SirT1 stimulates tumor cell proliferation.

Additional Information

Applications:	FA
Synonyms:	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, Selisistat, EX527, SIRT1 Inhibitor III
Formulation:	Crystalline solid
Chemical Name:	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Molecular Formula:	C₁₃H₁₃ClN₂O
Molecular Weight:	248.7
CAS Number	49843-98-3
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Gertz, M., Fischer, F., Nguyen, G. T. T., Lakshminarasimhan, M., Schutkowski, M., Weyand, M., & Steegborn, C. (2013). Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.Proceedings of the National Academy of Sciences, 110(30), E2772-E2781. Solomon, J. M., Pasupuleti, R., Xu, L., McDonagh, T., Curtis, R., DiStefano, P. S., & Huber, L. J. (2006). Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Molecular and cellular biology, 26(1), 28-38. Price, N. L., Gomes, A. P., Ling, A. J., Duarte, F. V., Martin-Montalvo, A., North, B. J., ... & Sinclair, D. A. (2012). SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell metabolism, 15(5), 675-690. Kabra, N., Li, Z., Chen, L., Li, B., Zhang, X., Wang, C., ... & Chen, J. (2009). SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. Journal of Biological Chemistry, 284(27), 18210-18217.