Dorsomorphin

Grouped product items
Size Price Qty
10mg
$140.00
50mg
$430.00
Catalog Number : 8666430

description

Dorsomorphin is a potent and selective inhibitor of the BMP pathway through the ALK2, ALK3, and ALK6 receptors. It is also a selective and reversible inhibitor of the AMP-activated protein kinase (AMPK). Dorsomorphin is reported to be useful in promoting specific cell differentiation and inducing cancer cell line autophagy.

Additional Information

Applications:
FA
Synonyms:
Compound C, AMPK Inhibitor, BML-275
Formulation:
Crystalline solid
Chemical Name:
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Molecular Formula:

C24H25N5O

Molecular Weight:
399.5
CAS Number
866405-64-3
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Paul, B. Y., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., ... & Peterson, R. T. (2008). Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology4(1), 33-41.

Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., ... & Hong, C. C. (2008). Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PloS one3(8), e2904.

Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology42(11), 1802-1807.

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