DMOG

Grouped product items
Size Price Qty
10mg
$20.00
50mg
$70.00
Catalog Number : 8946314

description

DMOG is a cell permeable Prolyl 4-hydroxylase (P4H) inhibitor which activates the hypoxia-inducible factor (HIF) in cultured cells. DMOG is reported to delay neuronal cell death caused by trophic factor deprivation through a HIF-1 alpha-independent, glucose-dependent mechanism.

Additional Information

Applications:
FA
Synonyms:
Dimethyloxallyl glycine, dimethyloxalylglycine, methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
Formulation:
Crystalline solid
Chemical Name:
methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetat
Molecular Formula:

C6H9NO5

Molecular Weight:
175.1
CAS Number
89464-63-1
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Hill, P., Shukla, D., Tran, M. G., Aragones, J., Cook, H. T., Carmeliet, P., & Maxwell, P. H. (2008). Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. Journal of the American Society of Nephrology19(1), 39-46.

Milkiewicz, M., Pugh, C. W., & Egginton, S. (2004). Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.The Journal of physiology560(1), 21-26.

Sears, J. E., Hoppe, G., Ebrahem, Q., & Anand-Apte, B. (2008). Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.Proceedings of the National Academy of Sciences105(50), 19898-19903.

© BioGems International, Inc. All rights reserved.