Compound E

Grouped product items
SizePrice Qty
1mg
$220.00
5mg
$795.00
Catalog Number : 2091746

description

Compound E is a potent cell-permeable inhibitor of gamma-secretase that blocks the cleavage of APP and Notch CTFs. It is reported to enhance the differentiation of embryonic stem cells into primitive neural stem cells.
product image

Additional Information

Applications:
FA
Synonyms:
gamma-Secretase Inhibitor XXI
Formulation:
Crystalline solid
Chemical Name:
(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide
Molecular Formula:

C27H24F2N4O3

Molecular Weight:
490.5
CAS Number
209986-17-4
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Liu, Y., Liu, H., Sauvey, C., Yao, L., Zarnowska, E. D., & Zhang, S. C. (2013). Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nature protocols8(9), 1670.

Schneider, J. W., Gao, Z., Li, S., Farooqi, M., Tang, T. S., Bezprozvanny, I., ... & Hsieh, J. (2008). Small-molecule activation of neuronal cell fate. Nature chemical biology4(7), 408.

Jurisch-Yaksi, N., Sannerud, R., & Annaert, W. (2013). A fast growing spectrum of biological functions of γ-secretase in development and disease. Biochimica et Biophysica Acta (BBA)-Biomembranes1828(12), 2815-2827.

© BioGems International, Inc. All rights reserved.