CNQX
Catalog Number : 1151436
description
CNQX is a potent AMPA/kainate receptor antagonist. It also acts an antagonist to the NMDA receptor complex at the glycine site. It is reported to block the excitatory action of kainate and quisqualate on spinal neurons with little or no effect on that of NMDA.
Additional Information
Applications:
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FA
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Synonyms:
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6-Cyano-2,3-dihydroxy-7-nitroquinoxaline, FG-9065
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Formulation:
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Crystalline solid
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Chemical Name:
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7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
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Molecular Formula:
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C9H4N4O4 |
Molecular Weight: |
232.2
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CAS Number
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115066-14-3
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Blake, J. F., Brown, M. W., & Collingridge, G. L. (1988). CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices. Neuroscience letters, 89(2), 182-186. Honoré, T., Drejer, J., Nielsen, E. Ø., & Nielsen, M. (1989). Non-NMDA glutamate receptor antagonist 3 H-CNQX binds with equal affinity to two agonist states of quisqualate receptors. Biochemical pharmacology, 38(19), 3207-3212. Long, S. K., Smith, D. A. S., Siarey, R. J., & Evans, R. H. (1990). Effect of 6‐cyano‐2, 3‐dihydroxy‐7‐nitro‐quinoxaline (CNQX) on dorsal root‐, NMDA‐, kainate‐and quisqualate‐mediated depolarization of rat motoneurones in vitro.British journal of pharmacology, 100(4), 850-854. |