CNQX

Grouped product items
SizePrice Qty
10mg
$70.00
50mg
$260.00
Catalog Number : 1151436

description

CNQX is a potent AMPA/kainate receptor antagonist. It also acts an antagonist to the NMDA receptor complex at the glycine site. It is reported to block the excitatory action of kainate and quisqualate on spinal neurons with little or no effect on that of NMDA.
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Additional Information

Applications:
FA
Synonyms:
6-Cyano-2,3-dihydroxy-7-nitroquinoxaline, FG-9065
Formulation:
Crystalline solid
Chemical Name:
7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
Molecular Formula:

C9H4N4O4

Molecular Weight:
232.2
CAS Number
115066-14-3
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Blake, J. F., Brown, M. W., & Collingridge, G. L. (1988). CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices. Neuroscience letters89(2), 182-186.

Honoré, T., Drejer, J., Nielsen, E. Ø., & Nielsen, M. (1989). Non-NMDA glutamate receptor antagonist 3 H-CNQX binds with equal affinity to two agonist states of quisqualate receptors. Biochemical pharmacology38(19), 3207-3212.

Long, S. K., Smith, D. A. S., Siarey, R. J., & Evans, R. H. (1990). Effect of 6‐cyano‐2, 3‐dihydroxy‐7‐nitro‐quinoxaline (CNQX) on dorsal root‐, NMDA‐, kainate‐and quisqualate‐mediated depolarization of rat motoneurones in vitro.British journal of pharmacology100(4), 850-854.

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