CH 223191

Grouped product items
Size Price Qty
10mg
$145.00
50mg
$600.00
Catalog Number : 3012272

description

CH 223191 is a specific and potent antagonist to the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that is involved in drug and xenobiotic metabolism. Unlike other AhR antagonists, it does not react with the estrogen receptor and is observed to effect AhR-dependent reporter gene expression in human, mouse, rat, and guinea pig cell lines. CH223191 is reported to exhibit AHR-independent pro-proliferative properties.

Additional Information

Applications:
FA
Synonyms:
AhR Antagonist, CH223191, AGN-PC-0KP4EW, Aryl hydrocarbon receptor antagonist
Formulation:
Crystalline solid
Chemical Name:
2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide
Molecular Formula:

C19H19N5O

Molecular Weight:
333.4
CAS Number
301326-22-7
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Zhao, B., DeGroot, D. E., Hayashi, A., He, G., & Denison, M. S. (2010). CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.Toxicological Sciences117(2), 393-403.

Choi, E. Y., Lee, H., Dingle, R. C., Kim, K. B., & Swanson, H. I. (2012). Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor. Molecular pharmacology81(1), 3-11.

Yoshida, T., Katsuya, K., Oka, T., Koizumi, S. I., Wakita, D., Kitamura, H., & Nishimura, T. (2012). Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells. Biomedical research33(2), 67-74.

 

© BioGems International, Inc. All rights reserved.