Cdk4 Inhibitor

Grouped product items
SizePrice Qty
1mg
$105.00
5mg
$455.00
Catalog Number : 5466072

description

Cdk4 Inhibitor is an indolocarbazole and potent inhibitor of cyclin D1/Cdk4. It induces G1 cell cycles arrest and inhibits the pRb phosphorylation in HCT-116 and NCI-H460 cells.
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Additional Information

Applications:
FA
Synonyms:
Cyclin-dependent kinase 4 Inhibitor
Formulation:
Crystalline solid
Chemical Name:
6-bromo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione
Molecular Formula:
C20H10BrN3O2
Molecular Weight:
404.2
CAS Number
546102-60-7
Purity:
≥90%
Storage Conditions:
Product should be kept at -20°C.
References:
Zhu, G., Conner, S. E., Zhou, X., Shih, C., Li, T., Anderson, B. D., ... & Faul, M. M. (2003). Synthesis, structure− activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. Journal of medicinal chemistry, 46(11), 2027-2030. Sun, Y., Li, Y. X., Wu, H. J., Wu, S. H., Wang, Y. A., Luo, D. Z., & Liao, D. J. (2011). Effects of an indolocarbazole-derived CDK4 inhibitor on breast cancer cells. Journal of Cancer, 2, 36.
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