(-)-Blebbistatin
Catalog Number : 8567182
description
(-)-Blebbistatin is an Active enantiomer that selectively inhibits non-muscle myosin II ATPase activity and inhibits of smooth muscle myosin to a much lesser degree. Its effects can be inactivated by UV light and it is capable of rapidly and reversibly blocking cell blebbing by altering the forces that impinge on the cytoskeleton-membrane interface.
Additional Information
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Applications:
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FA
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Synonyms:
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(S)-(-)-Blebbistatin
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Formulation:
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Crystalline solid
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Chemical Name:
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1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one
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Molecular Formula:
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C18H16N2O2 |
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Molecular Weight: |
292.3
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CAS Number
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856925-71-8
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Kovács, M., Tóth, J., Hetényi, C., Málnási-Csizmadia, A., & Sellers, J. R. (2004). Mechanism of blebbistatin inhibition of myosin II. Journal of Biological Chemistry, 279(34), 35557-35563. Allingham, J. S., Smith, R., & Rayment, I. (2005). The structural basis of blebbistatin inhibition and specificity for myosin II. Nature structural & molecular biology, 12(4), 378-379. Kolega, J. (2004). Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochemical and biophysical research communications, 320(3), 1020-1025. |