BIX 01294

Grouped product items
SizePrice Qty
10mg
$155.00
50mg
$510.00
Catalog Number : 1806425

description

BIX 01294 is a diazepin-quinazolinamine derivate and G9a and GLP histone methyltransferase inhibitor. It is reported to function by blocking the histone binding sites. BIX01294 modulates the epigenetic status of chromatin and has been used to improve the reprogramming efficiency of iPSC generation.
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Additional Information

Applications:
FA
Synonyms:
BIX01294, BIX-01294, BIX01294 hydrochloride hydrate
Formulation:
Crystalline solid
Chemical Name:
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4a,8a-dihydroquinazolin-4-amine
Molecular Formula:

C28H38N6O2 3HCl xH2O

Molecular Weight:
600.0
CAS Number
1808255-64-2
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Ling, B. M. T., Bharathy, N., Chung, T. K., Kok, W. K., Li, S., Tan, Y. H., ... & Taneja, R. (2012). Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proceedings of the National Academy of Sciences109(3), 841-846.

Culmes, M., Eckstein, H. H., Burgkart, R., Nüssler, A. K., Guenther, M., Wagner, E., & Pelisek, J. (2013). Endothelial differentiation of adipose-derived mesenchymal stem cells is improved by epigenetic modifying drug BIX-01294. European journal of cell biology92(2), 70-79.

Chang, Y., Zhang, X., Horton, J. R., Upadhyay, A. K., Spannhoff, A., Liu, J., ... & Cheng, X. (2009). Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nature Structural and Molecular Biology16(3), 312.

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