BI-D1870
Catalog Number : 5012813
description
BI-D1870 is a cell permeable and highly specific inhibitor of the ribosomal S6 kinases (RSK 1-4). The RSKs are highly conserved Ser/Thr kinases that promote cell proliferation, growth, motility and survival. It is also reported to prevent gamma irradiation-induced apoptosis and to drive the cells to senescence.
Additional Information
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Applications:
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FA
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Synonyms:
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CHEMBL573107, GTPL8038, AB0007926, S14-0516, 2-[ AMINO]-7,8-DIHYDRO-5,7-DIMETHYL-8- -6 -PTERIDINONE
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Formulation:
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Crystalline solid
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Chemical Name:
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2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one
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Molecular Formula:
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C19H23F2N5O2 |
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Molecular Weight: |
391.4
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CAS Number
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501437-28-1
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Neise, D., Sohn, D., Stefanski, A., Goto, H., Inagaki, M., Wesselborg, S., ... & Jänicke, R. U. (2013). The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK-and p53-independent accumulation of p21WAF1/CIP1. Cell death & disease, 4(10), e859. Nguyen, T. L. (2008). Targeting RSK: an overview of small molecule inhibitors.Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 8(7), 710-716. Sapkota, G., Cummings, L., Newell, F., Armstrong, C., Bain, J., Frodin, M., ... & Alessi, D. (2007). BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem. J, 401, 29-38. |