BAY 11-7082

Grouped product items
Size Price Qty
10mg
$85.00
25mg
$195.00
Catalog Number : 1956772

description

Bay 11-7082 is a selective and irreversible inhibitor of TNF alpha induced IκBα phosphorylation and the binding of ubiquitin. It is reported to induce apoptosis in several B and T lymphoma cell lines and TNF-alpha induced expression of several adhesion molecules.

Additional Information

Applications:
FA
Synonyms:
(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Formulation:
Crystalline solid
Chemical Name:
(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile
Molecular Formula:

C10H9NO2S

Molecular Weight:
207.3
CAS Number
19542-67-7
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Mori, N., Yamada, Y., Ikeda, S., Yamasaki, Y., Tsukasaki, K., Tanaka, Y., ... & Fujii, M. (2002). Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I–infected T-cell lines and primary adult T-cell leukemia cells. Blood100(5), 1828-1834.

Lappas, M., Yee, K., Permezel, M., & Rice, G. E. (2005). Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-κB and IκB kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology146(3), 1491-1497.

García, M. G., Alaniz, L., Lopes, E. C., Blanco, G., Hajos, S. E., & Alvarez, E. (2005). Inhibition of NF-κB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines. Leukemia research29(12), 1425-1434.

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