AS 8351

Grouped product items
SizePrice Qty
10mg
$100.00
25mg
$235.00
Catalog Number : 7964296

description

AS 8351 is an iron chelator and histone demethylase inhibitor, targeting KDM5B (JARID1B). It is reported to efficiently induce cardiac reprogramming of human fibroblasts in conjunction with other small molecules. KDM5B is a multi-domain demethylase enzyme that is overexpressed in many cancer types.
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Additional Information

Applications:
FA
Synonyms:
AS8351, AS-8351, NSC-51355, 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone
Formulation:
Crystalline solid
Chemical Name:
N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
Molecular Formula:

C17H13N3O2

Molecular Weight:
291.3
CAS Number
796-42-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Cao, N., Huang, Y., Zheng, J., Spencer, C. I., Zhang, Y., Fu, J. D., ... & Ma, T. (2016). Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science352(6290), 1216-1220.

Chen, Y., Yang, Z., Zhao, Z. A., & Shen, Z. (2017). Direct reprogramming of fibroblasts into cardiomyocytes. Stem cell research & therapy8(1), 118.

Hayami, S., Yoshimatsu, M., Veerakumarasivam, A., Unoki, M., Iwai, Y., Tsunoda, T., ... & Ponder, B. A. (2010). Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Molecular cancer9(1), 59.

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