AG 1478

Grouped product items
SizePrice Qty
10mg
$150.00
25mg
$330.00
Catalog Number : 1535346

description

AG 1478 is a potent and selective epidermal growth factor receptor (EGFR) kinase inhibitor. It is reported to inhibit cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells and a suppressor of leiomyoma cell growth.
product image

Additional Information

Applications:
FA
Synonyms:
AG1478, AG-1478, tyrphostin-AG1478, TYRPHOSTIN
Formulation:
Crystalline solid
Chemical Name:
N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
Molecular Formula:

C16H14ClN3O2

Molecular Weight:
315.8
CAS Number
153436-53-4
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Zhu, X. F., Liu, Z. C., Xie, B. F., Li, Z. M., Feng, G. K., Yang, D., & Zeng, Y. X. (2001). EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells. Cancer letters169(1), 27-32.

Zhang, Y. G., Du, Q., Fang, W. G., Jin, M. L., & Tian, X. X. (2008). Tyrphostin AG1478 suppresses proliferation and invasion of human breast cancer cells. International journal of oncology33(3), 595-602.

Caja, L., Sancho, P., Bertran, E., Ortiz, C., Campbell, J. S., Fausto, N., & Fabregat, I. (2011). The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms. Biochemical pharmacology82(11), 1583-1592.

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