5-Azacytidine
Catalog Number : 3206727
description
5-Azacytidine is a DNA methyltransferase inhibitor that induces the demethylation and reactivation of silenced genes. It is an epigenetic modifier and chemical analogue of cytidine, a DNA and RNA nucleotide. 5-Azacytidine is reported to inhibit the proliferation of several cancer cell lines by reducing hypermethylation and is useful for stem cell research as it can enhance the differentiation of embryonic stem cells into cardiomyocytes and reset the epigenetic memory of mouse IPS cells. A recent study reported that 5-Azacytidine in conjunction with PDGF-AB can induce the conversion of somatic cells into tissue-regenerative multipotent stem cells.
Additional Information
Applications:
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FA
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Synonyms:
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Ladakamycin, NSC 102816, Vidaza
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Formulation:
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Crystalline solid
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Chemical Name:
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4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
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Molecular Formula:
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C8H12N4O5 |
Molecular Weight: |
244.2
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CAS Number
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320-67-2
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Chandrakanthan, V., Yeola, A., Kwan, J. C., Oliver, R. A., Qiao, Q., Kang, Y. C., ... & Villanueva, J. E. (2016). PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.Proceedings of the National Academy of Sciences, 201518244. Christman, J. K. (2002). 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene, 21(35), 5483-5495. Wakitani, S., Saito, T., & Caplan, A. I. (1995). Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5‐azacytidine. Muscle & nerve, 18(12), 1417-1426. Jones, P. A. (1985). Altering gene expression with 5-azacytidine. Cell, 40(3), 485-486. |