IDE2

Grouped product items
Size Price Qty
1mg
$35.00
10mg
$185.00
Catalog Number : 1139374

description

IDE2 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.

Additional Information

Applications:
FA
Synonyms:
1DE 2, Inducer of Definitive Endoderm 2
Formulation:
Crystalline solid
Chemical Name:
Heptanedioic acid-1-(2-cyclopentylidenehydrazide)
Molecular Formula:

C12H20N2O3

Molecular Weight:
240.3
CAS Number
1136466-93-7
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., ... & Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell4(4), 348-358.

Li, W., & Ding, S. (2010). Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends in pharmacological sciences,31(1), 36-45.

Aguayo-Mazzucato, C., & Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus. Nature Reviews Endocrinology6(3), 139-148.

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