IDE2
Catalog Number : 1139374
description
IDE2 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.
Additional Information
Applications:
|
FA
|
Synonyms:
|
1DE 2, Inducer of Definitive Endoderm 2
|
Formulation:
|
Crystalline solid
|
Chemical Name:
|
Heptanedioic acid-1-(2-cyclopentylidenehydrazide)
|
Molecular Formula:
|
C12H20N2O3 |
Molecular Weight: |
240.3
|
CAS Number
|
1136466-93-7
|
Purity:
|
≥98%
|
Storage Conditions:
|
Product should be kept at -20°C.
|
References:
|
Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., ... & Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell, 4(4), 348-358. Li, W., & Ding, S. (2010). Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends in pharmacological sciences,31(1), 36-45. Aguayo-Mazzucato, C., & Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus. Nature Reviews Endocrinology, 6(3), 139-148. |