IDE1

Grouped product items
SizePrice Qty
1mg
$55.00
10mg
$190.00
Catalog Number : 1164899

description

IDE1 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.
product image

Additional Information

Applications:
FA
Synonyms:
1DE 1, Inducer of Definitive Endoderm 1
Formulation:
Crystalline solid
Chemical Name:
1-[2-[(2-carboxyphenyl)methylene]hydrazide]-heptanedioic acid
Molecular Formula:

C15H18N2O5

Molecular Weight:
306.3
CAS Number
1160927-48-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Hoveizi, E., Nabiuni, M., Parivar, K., Ai, J., & Massumi, M. (2014). Definitive endoderm differentiation of human‐induced pluripotent stem cells using signaling molecules and IDE1 in three‐dimensional polymer scaffold. Journal of Biomedical Materials Research Part A102(11), 4027-4036.

Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., ... & Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell4(4), 348-358.

Aguayo-Mazzucato, C., & Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus. Nature Reviews Endocrinology6(3), 139-148.

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