HPI-1
Catalog Number : 5992065
description
HPI-1 is a hedgehog (Hh) signaling inhibitor without significantly effecting Wnt signaling. It inhibits Gli1 and Gli2 induced activation and the proliferation of SmoM2 expressing cell lines.
Additional Information
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Applications:
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FA
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Synonyms:
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ST093553, AC1MFWGY, Hedgehog pathway inhibitor 1
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Formulation:
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Crystalline solid
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Chemical Name:
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2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
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Molecular Formula:
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C27H29NO6 |
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Molecular Weight: |
463.5
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CAS Number
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599150-20-6
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Xu, Y., Chenna, V., Hu, C., Sun, H. X., Khan, M., Bai, H., ... & Anders, R. A. (2012). Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma. Clinical Cancer Research, 18(5), 1291-1302. Hyman, J. M., Firestone, A. J., Heine, V. M., Zhao, Y., Ocasio, C. A., Han, K., ... & Chen, J. K. (2009). Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences, 106(33), 14132-14137. Merchant, A. A., & Matsui, W. (2010). Targeting Hedgehog—a cancer stem cell pathway. Clinical Cancer Research, 16(12), 3130-3140. |