Cyclopamine

Grouped product items
SizePrice Qty
1mg
$20.00
10mg
$95.00
Catalog Number : 4445185

description

Cyclopamine is a steroidal alkaloid inhibitor of the hedgehog signaling pathway (Hh), an essential pathway for embryonic development. It is reported to be capable of inducing differentiation of stem cells into endocrine cells and various anti-cancer applications by suppressing excess Hh activity.
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Additional Information

Applications:
FA
Synonyms:
11-Deoxojervine, MLS006010945, Jervine
Formulation:
Crystalline solid
Chemical Name:
(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
Molecular Formula:

C27H41NO2

Molecular Weight:
411.6
CAS Number
4449-51-8
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., ... & Beachy, P. A. (2000). Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature406(6799), 1005-1009.

Chen, J. K., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002). Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes & development16(21), 2743-2748.

Bar, E. E., Chaudhry, A., Lin, A., Fan, X., Schreck, K., Matsui, W., ... & Eberhart, C. G. (2007). Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma. Stem cells25(10), 2524-2533.

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