CUR-61414

Grouped product items
SizePrice Qty
5mg
$110.00
10mg
$205.00
Catalog Number : 3343668

description

CUR-61414 is a potent antagonist of SMO (smoothened) in the hedgehog signaling pathway. Smoothened can function as an oncogene and CUR-61414 is reported to block proliferation and induce apoptosis in cancer cells.
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Additional Information

Applications:
FA
Synonyms:
CUR 61414, CUR61414, G-024586
Formulation:
Crystalline solid
Chemical Name:
N-[1-(1,3-benzodioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
Molecular Formula:

C31H42N4O5

Molecular Weight:
550.7
CAS Number
334998-36-6
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Williams, J. A. (2003). Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma. Drug News Perspect,16(10), 657-662.

Rubin, L. L., & de Sauvage, F. J. (2006). Targeting the Hedgehog pathway in cancer. Nature reviews Drug discovery5(12), 1026-1033.

Stanton, B. Z., & Peng, L. F. (2010). Small-molecule modulators of the Sonic Hedgehog signaling pathway. Molecular BioSystems6(1), 44-54.

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