GSK923295

Grouped product items
SizePrice Qty
5mg
$140.00
50mg
$1,000.00
Catalog Number : 1083707

description

GSK923295 is a potent and selective mitotic kinesin Centromere protein E (CENP-E) inhibitor, a protein that accumulates in the G2 phase of the cell cycle. It is proposed to be one of the motors responsible for mammalian chromosome movement and spindle elongation. GSK923295 induces mitotic arrest and chromosome alignment failure. It is reported to be a potent inhibitor of tumor cell growth, which is further enhanced when MEK/ERK signaling is also inhibited.
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Additional Information

Applications:
FA
Synonyms:
GSK-923295
Formulation:
Crystalline solid
Chemical Name:
3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide
Molecular Formula:

C32H38ClN5O4

Molecular Weight:
592.1
CAS Number
1088965-37-0
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Chung, V., Heath, E. I., Schelman, W. R., Johnson, B. M., Kirby, L. C., Lynch, K. M., ... & Holen, K. D. (2012). First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer. Cancer chemotherapy and pharmacology69(3), 733-741.

Qian, X., McDonald, A., Zhou, H. J., Adams, N. D., Parrish, C. A., Duffy, K. J., ... & Jiang, H. (2010). Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295. ACS medicinal chemistry letters1(1), 30-34.

Wacker, S. A., & Kapoor, T. M. (2010). Targeting a kinetochore-associated motor protein to kill cancer cells. Proceedings of the National Academy of Sciences107(13), 5699-5700.

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