FTY720

Grouped product items
SizePrice Qty
50mg
$60.00
100mg
$110.00
Catalog Number : 1625605

description

FTY720 is a sphingosine-1-phosphate receptor modulator that sequesters lymphocytes in lymph nodes, inhibiting their contribution to autoimmune responses. It is derived from myriocin (ISP-1), a fungal metabolite. FTY720 is also reported to be a cPLA2 inhibitor, a ceramide synthase inhibitor, and a cannabinoid receptor antagonist.
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Additional Information

Applications:
FA
Synonyms:
Fingolimod hydrochloride, Fty-720, Fingolimod HCl
Formulation:
Crystalline solid
Chemical Name:
2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride
Molecular Formula:

C19H33NOHCl

Molecular Weight:
343.9
CAS Number
162359-56-0
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., ... & Lynch, K. R. (2002). The immune modulator FTY720 targets sphingosine 1-phosphate receptors. Journal of Biological Chemistry277(24), 21453-21457.

Gräler, M. H., & Goetzl, E. J. (2004). The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. The FASEB journal18(3), 551-553.

Chiba, K., Yanagawa, Y., Masubuchi, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M., & Hoshino, Y. (1998). FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. The Journal of Immunology160(10), 5037-5044.

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