FTY720
description
Additional Information
Applications:
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FA
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Synonyms:
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Fingolimod hydrochloride, Fty-720, Fingolimod HCl
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Formulation:
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Crystalline solid
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Chemical Name:
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2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride
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Molecular Formula:
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C19H33NO2 HCl |
Molecular Weight: |
343.9
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CAS Number
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162359-56-0
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., ... & Lynch, K. R. (2002). The immune modulator FTY720 targets sphingosine 1-phosphate receptors. Journal of Biological Chemistry, 277(24), 21453-21457. Gräler, M. H., & Goetzl, E. J. (2004). The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. The FASEB journal, 18(3), 551-553. Chiba, K., Yanagawa, Y., Masubuchi, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M., & Hoshino, Y. (1998). FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. The Journal of Immunology, 160(10), 5037-5044. |