Forskolin

Grouped product items
SizePrice Qty
10mg
$70.00
50mg
$135.00
Catalog Number : 6652995

description

Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cyclic AMP (cAMP). It has vasodilator and hypotensive properties and can be used to induce neuronal differentiation in stem cells. In combination with other small molecules, it is also reported to be utilized in the chemical reprogramming of embryonic fibroblasts to induced pluripotent stem cells.
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Additional Information

Applications:
FA
Synonyms:
Coleonol, colforsin, NKH-477, NSC 375489
Formulation:
Crystalline solid
Chemical Name:
[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
Molecular Formula:

C22H34O7

Molecular Weight:
410.5
CAS Number
66575-29-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Seamon, K. B., & Daly, J. W. (1980). Forskolin: a unique diterpene activator of cyclic AMP-generating systems. Journal of cyclic nucleotide research7(4), 201-224.

Laurenza, A., Sutkowski, E. M., & Seamon, K. B. (1989). Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?.Trends in Pharmacological Sciences10(11), 442-447.

Shamblott, M. J., Axelman, J., Wang, S., Bugg, E. M., Littlefield, J. W., Donovan, P. J., ... & Gearhart, J. D. (1998). Derivation of pluripotent stem cells from cultured human primordial germ cells. Proceedings of the National Academy of Sciences95(23), 13726-13731.

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