Diazoxide

Grouped product items
Size	Price	Qty
100mg	$65.00

Catalog Number : 3649874

description

Diazoxide is a potassium channel activator and vasodilator. It is reported to inhibit the secretion of insulin by the opening of the ATP-sensitive potassium channel of beta cells of the pancreas and to block the desensitization of AMPA receptors.

Additional Information

Applications:	FA
Synonyms:	Proglycem, Hyperstat, NSC 64198, Mutabase
Formulation:	Crystalline solid
Chemical Name:	7-chloro-3-methyl-4H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide
Molecular Formula:	C₈H₇ClN₂O₂S
Molecular Weight:	230.7
CAS Number	364-98-7
Purity:	≥99%
Storage Conditions:	Product should be kept at -20°C.
References:	Garlid, K. D., Paucek, P., Yarov-Yarovoy, V., Murray, H. N., Darbenzio, R. B., D’Alonzo, A. J., ... & Grover, G. J. (1997). Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels: possible mechanism of cardioprotection. Circulation research, 81(6), 1072-1082. NESTLER, J. E., BARLASCINI, C. O., MATT, D. W., STEINGOLD, K. A., PLYMATE, S. R., CLORE, J. N., & BLACKARD, W. G. (1989). Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism, 68(6), 1027-1032. Korge, P., Honda, H. M., & Weiss, J. N. (2002). Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning. Proceedings of the National Academy of Sciences, 99(5), 3312-3317.