Cyclopamine
Catalog Number : 4445185
description
Cyclopamine is a steroidal alkaloid inhibitor of the hedgehog signaling pathway (Hh), an essential pathway for embryonic development. It is reported to be capable of inducing differentiation of stem cells into endocrine cells and various anti-cancer applications by suppressing excess Hh activity.
Additional Information
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Applications:
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FA
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Synonyms:
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11-Deoxojervine, MLS006010945, Jervine
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Formulation:
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Crystalline solid
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Chemical Name:
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(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
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Molecular Formula:
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C27H41NO2 |
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Molecular Weight: |
411.6
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CAS Number
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4449-51-8
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., ... & Beachy, P. A. (2000). Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature, 406(6799), 1005-1009. Chen, J. K., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002). Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes & development, 16(21), 2743-2748. Bar, E. E., Chaudhry, A., Lin, A., Fan, X., Schreck, K., Matsui, W., ... & Eberhart, C. G. (2007). Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma. Stem cells, 25(10), 2524-2533. |