Compound E
Catalog Number : 2091746
description
Compound E is a potent cell-permeable inhibitor of gamma-secretase that blocks the cleavage of APP and Notch CTFs. It is reported to enhance the differentiation of embryonic stem cells into primitive neural stem cells.
Additional Information
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Applications:
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FA
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Synonyms:
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gamma-Secretase Inhibitor XXI
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Formulation:
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Crystalline solid
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Chemical Name:
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(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide
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Molecular Formula:
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C27H24F2N4O3 |
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Molecular Weight: |
490.5
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CAS Number
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209986-17-4
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Liu, Y., Liu, H., Sauvey, C., Yao, L., Zarnowska, E. D., & Zhang, S. C. (2013). Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nature protocols, 8(9), 1670. Schneider, J. W., Gao, Z., Li, S., Farooqi, M., Tang, T. S., Bezprozvanny, I., ... & Hsieh, J. (2008). Small-molecule activation of neuronal cell fate. Nature chemical biology, 4(7), 408. Jurisch-Yaksi, N., Sannerud, R., & Annaert, W. (2013). A fast growing spectrum of biological functions of γ-secretase in development and disease. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1828(12), 2815-2827. |