CHIR 99021

Grouped product items
Size	Price	Qty
1mg	$40.00
10mg	$160.00

Catalog Number : 2520691

description

CHIR 99021 is an aminopyrimidine derivate that is a selective and potent inhibitor of glycogen synthase kinase 3 (GSK-3). It is used to maintain human and mouse stem cell lines and, in combination with other reagents, to chemically reprogram somatic cells into stem cells.

Additional Information

Applications:	FA
Synonyms:	Chir99021, CHEMBL412142, GSK-3 Inhibitor XVI, AGN-PC-0MWAEX
Formulation:	Crystalline solid
Chemical Name:	6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
Molecular Formula:	C₂₂H₁₈Cl₂N₈
Molecular Weight:	465.3
CAS Number	252917-06-9
Purity:	≥95%
Storage Conditions:	Product should be kept at -20°C.
References:	Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., ... & Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell stem cell, 4(1), 16-19. Ye, S., Tan, L., Yang, R., Fang, B., Qu, S., Schulze, E. N., ... & Li, P. (2012). Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PloS one,7(4), e35892. Wu, Y., Ai, Z., Yao, K., Cao, L., Du, J., Shi, X., ... & Zhang, Y. (2013). CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression. Experimental cell research, 319(17), 2684-2699.