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(-)-Blebbistatin



Catalog Number : 8567182

Description

(-)-Blebbistatin is an Active enantiomer that selectively inhibits non-muscle myosin II ATPase activity and inhibits of smooth muscle myosin to a much lesser degree. Its effects can be inactivated by UV light and it is capable of rapidly and reversibly blocking cell blebbing by altering the forces that impinge on the cytoskeleton-membrane interface.
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Additional Information

Applications:
FA
Synonyms:
(S)-(-)-Blebbistatin
Formulation:
Crystalline solid
Chemical Name:
1,2,3,3a-tetrahydro-3aS-hydroxy-6-methyl-1-phenyl-4H-Pyrrolo[2,3-b]quinolin-4-one
Molecular Formula:

C18H16N2O2

Molecular Weight:
292.3
CAS Number
856925-71-8
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Kovács, M., Tóth, J., Hetényi, C., Málnási-Csizmadia, A., & Sellers, J. R. (2004). Mechanism of blebbistatin inhibition of myosin II. Journal of Biological Chemistry279(34), 35557-35563.

Allingham, J. S., Smith, R., & Rayment, I. (2005). The structural basis of blebbistatin inhibition and specificity for myosin II. Nature structural & molecular biology12(4), 378-379.

Kolega, J. (2004). Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochemical and biophysical research communications320(3), 1020-1025.


Availability: In stock

Size Price Qty
1mg
$35.00
5mg
$140.00