Trichostatin A

Grouped product items
SizePrice Qty
1mg
$105.00
10mg
$770.00
Catalog Number : 5881960

description

Trichostatin A (TSA) is an antifungal antibiotic and a selective class I and II histone deacetylase inhibitor. It prevents the removal of acetyl groups from lysine residues on histone tails and can also be used to inhibit the cell cycle of eukaryotic cells at the beginning of their growth stage. TSA is also reported to have anti-cancer properties by promoting the expression of apoptosis related genes. It is also been used to increase the efficiency of the reprogramming of induced pluripotent stem cells and as a useful epigenetic modifier.
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Additional Information

Applications:
FA
Synonyms:
TSA, GNF-PF-1011
Formulation:
Crystalline solid
Chemical Name:
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
Molecular Formula:

C17H22N2O3

Molecular Weight:
302.4
CAS Number
58880-19-6
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Ji, Q., Zhu, K., Liu, Z., Song, Z., Huang, Y., Zhao, H., ... & Cong, P. (2013). Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis. Theriogenology79(5), 815-823.

Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A. E., & Melton, D. A. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature biotechnology26(7), 795-797.

Kim, K., Doi, A., Wen, B., Ng, K., Zhao, R., Cahan, P., ... & Daley, G. Q. (2010). Epigenetic memory in induced pluripotent stem cells. Nature,467(7313), 285-290.

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