Puromycin dihydrochloride
Catalog Number : 5855822
description
Puromycin is an aminonucleoside antibiotic and protein synthesis inhibitor. It is a reversible inhibitor of dipeptidyl-pepdidase II (serine peptidase) and cytosol alanyl aminopeptidase. Puromycin functions by inhibiting translation and it also inhibits the transportation of protein into the mitochondria.
Additional Information
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Applications:
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FA
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Synonyms:
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Puromycin HCl, Stylomycin hydrochloride, CL13900, P-638
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Formulation:
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Crystalline solid
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Chemical Name:
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(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride
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Molecular Formula:
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C22H29N7O5 2HCl |
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Molecular Weight: |
544.4
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CAS Number
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58-58-2
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Traut, R. R., & Monro, R. E. (1964). The puromycin reaction and its relation to protein synthesis. Journal of molecular biology, 10(1), 63-72. Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., & Yamanaka, S. (2008). Generation of mouse induced pluripotent stem cells without viral vectors.Science, 322(5903), 949-953. Vara, J. A., Portela, A., Ortìn, J., & Jimenez, A. (1986). Expression in mammalian cells of a gene from Streptomyces alboniger conferring puromycin resistance. Nucleic acids research, 14(11), 4617-4624. |