Monensin sodium salt

Grouped product items
Size Price Qty
1g
$45.00
10g
$385.00
Catalog Number : 2237803

description

Monensin is a polyether ionophore antibiotic that blocks intracellular protein transport. Monensin exhibits antibiotic, antimalarial, and other biological activities. It is reported to inhibit the proliferation and induce apoptosis of several cancer cell lines.

Additional Information

Applications:
FA
Synonyms:
Coban, Monensin, Monensin Monosodium Salt, Monensin-A-Sodium Complex, Rumensin
Formulation:
Crystalline solid
Chemical Name:
sodium;(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate
Molecular Formula:

C36H61O11 Na

Molecular Weight:
692.9
CAS Number
22373-78-0
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Mollenhauer, H. H., Morré, D. J., & Rowe, L. D. (1990). Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes1031(2), 225-246

Griffiths, G., Quinn, P., & Warren, G. (1983). Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. The Journal of Cell Biology96(3), 835-850.

Ketola, K., Vainio, P., Fey, V., Kallioniemi, O., & Iljin, K. (2010). Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells. Molecular cancer therapeutics9(12), 3175-3185.

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