Ionomycin Calcium Salt
Catalog Number : 5608212
description
Ionomycin is an ionphore discovered in Streptomyces conglobatus and used in the study of intracellular calcium. It is also reported to stimulate the intracellular production of IL-2, IL-4 and perforin. It is supplied as a a calcium salt for ease of storage.
Additional Information
Applications:
|
FA
|
Synonyms:
|
IONOMYCINCALCIUMSALT
|
Formulation:
|
Crystalline solid
|
Chemical Name:
|
calcium;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate
|
Molecular Formula:
|
C41H70O9 Ca |
Molecular Weight: |
747.1
|
CAS Number
|
56092-82-1
|
Purity:
|
≥98%
|
Storage Conditions:
|
Product should be kept at -20°C.
|
References:
|
Liu, C. M., & Hermann, T. E. (1978). Characterization of ionomycin as a calcium ionophore. Journal of Biological Chemistry, 253(17), 5892-5894. Morgan, A. J., & Jacob, R. (1994). Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane. Biochem. J, 300, 665-672. Elzi, D. J., Bjornsen, A. J., MacKenzie, T., Wyman, T. H., & Silliman, C. C. (2001). Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. American Journal of Physiology-Cell Physiology, 281(1), C350-C360. |