Filipin III

Grouped product items
Size Price Qty
1mg
$140.00
5mg
$550.00
Catalog Number : 4804999

description

Filipin III is the most prevalent isomer of the Filipin complex, a potent polyene macrolide antibiotic and antifungal mixture. It is reported that it functions by disrupting the cell membrane. Filipin is also used as a histochemical stain for cholesterol as it is highly fluorescent and to inhibit the raft/caveolae endocytosis pathway in mammalian cells.

Additional Information

Applications:
FA
Synonyms:
Filimirasin, Filmirisin
Formulation:
Crystalline solid
Chemical Name:
(17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Molecular Formula:

C35H58O11

Molecular Weight:
654.8
CAS Number
480-49-9
Purity:
≥85%
Storage Conditions:
Product should be kept at -20°C.
References:

Bittman, R., & Fischkoff, S. A. (1972). Fluorescence studies of the binding of the polyene antibiotics filipin III, amphotericin B, nystatin, and lagosin to cholesterol. Proceedings of the National Academy of Sciences69(12), 3795-3799.

Pandey, R. G., & RINEHART, K. L. (1970). POLYENE ANTIBIOTICS. V. CHARACTERIZATION OF COMPONENTS OF THE FILIPIN COMPLEX BY MASS SPECTROMETRY 1). The Journal of antibiotics23(8), 414-417.

Orlandi, P. A., & Fishman, P. H. (1998). Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains. The Journal of cell biology141(4), 905-915.

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