Brefeldin A

Grouped product items
SizePrice Qty
5mg
$40.00
25mg
$105.00
Catalog Number : 2031560

description

Brefeldin A is a lactone antibiotic originating discovered in fungi capable of inhibiting protein transport from the endolasmic reticulum to the Golgi apparatus. It is reported to act on the guanine nucleotide exchange factor named GBF1 that mediates the formation of transport vesicles and the unfolded protein response can result in apoptosis in some cells.
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Additional Information

Applications:
FA
Synonyms:
Ascotoxin, Cyanein, Decumbin, Synergisidin
Formulation:
Crystalline solid
Chemical Name:
(1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one
Molecular Formula:

C16H24O4

Molecular Weight:
280.4
CAS Number
20350-15-6
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Misumi, Y., Miki, K., Takatsuki, A., Tamura, G., & Ikehara, Y. (1986). Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. Journal of Biological Chemistry261(24), 11398-11403.

Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S., & Klausner, R. D. (1989). Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell56(5), 801-813.

Fujiwara, T., Oda, K., Yokota, S., Takatsuki, A., & Ikehara, Y. (1988). Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. Journal of Biological Chemistry263(34), 18545-18552.

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