AM 580

Grouped product items
Size	Price	Qty
10mg	$125.00
25mg	$275.00

Catalog Number : 1026081

description

AM 580 is a retinoic acid analog that is used as a selective agonist to RARα. It is reported to induce cell differentiation at a 7 fold increase over the activity of retinoic acid in vitro. AM 580 promotes the reprogramming of somatic cells to induced pluripotent stem cells and inhibits tumor cell proliferation.

Additional Information

Applications:	FA
Synonyms:	AM580; AM-580; AM 580; CD-336; CD336; NSC 608001
Formulation:	Crystalline solid
Chemical Name:	4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid
Molecular Formula:	C₂₂H₂₅NO₃
Molecular Weight:	351.4
CAS Number	102121-60-8
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Gianni, M., Calzi, M. L., Terao, M., Guiso, G., Caccia, S., Barbui, T., ... & Garattini, E. (1996). AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood, 87(4), 1520-1531. Wang, W., Yang, J., Liu, H., Lu, D., Chen, X., Zenonos, Z., ... & Bradley, A. (2011). Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proceedings of the National Academy of Sciences, 108(45), 18283-18288. Tamura, K., Kagechika, H., Hashimoto, Y., Ohsugi, K., Shudo, K., & Ide, H. (1990). Synthetic retinoids, retinobenzoic acids, Am80, Am580 and Ch55 regulate morphogenesis in chick limb bud. Cell Differentiation and Development, 32(1), 17-26.