RS-1

Grouped product items
SizePrice Qty
10mg
$75.00
50mg
$290.00
Catalog Number : 3127446

description

RS-1 is a stimulator of RAD51, a DNA repair protein. It is reported to function by stabilizing the active form and the DNA binding activity of RAD51. RS-1 enhances homology-directed repair 3-6 fold and CRISPR-Cas9 knock-in efficiency.
product image

Additional Information

Applications:
FA
Synonyms:
RAD51-Stimulatory Compound-1, RS1, MFCD00348720
Formulation:
Crystalline solid
Chemical Name:
3-(benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide
Molecular Formula:

C20H16Br2N2O3S

Molecular Weight:
524.2
CAS Number
312756-74-4
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Song, J., Yang, D., Xu, J., Zhu, T., Chen, Y. E., & Zhang, J. (2016). RS-1 enhances CRISPR/Cas9-and TALEN-mediated knock-in efficiency. Nature communications7.

Pinder, J., Salsman, J., & Dellaire, G. (2015). Nuclear domain ‘knock-in’screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing. Nucleic acids research, gkv993.

Jayathilaka, K., Sheridan, S. D., Bold, T. D., Bochenska, K., Logan, H. L., Weichselbaum, R. R., ... & Connell, P. P. (2008). A chemical compound that stimulates the human homologous recombination protein RAD51. Proceedings of the National Academy of Sciences105(41), 15848-15853.

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