RS-1
Catalog Number : 3127446
description
RS-1 is a stimulator of RAD51, a DNA repair protein. It is reported to function by stabilizing the active form and the DNA binding activity of RAD51. RS-1 enhances homology-directed repair 3-6 fold and CRISPR-Cas9 knock-in efficiency.
Additional Information
Applications:
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FA
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Synonyms:
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RAD51-Stimulatory Compound-1, RS1, MFCD00348720
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Formulation:
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Crystalline solid
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Chemical Name:
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3-(benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide
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Molecular Formula:
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C20H16Br2N2O3S |
Molecular Weight: |
524.2
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CAS Number
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312756-74-4
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Song, J., Yang, D., Xu, J., Zhu, T., Chen, Y. E., & Zhang, J. (2016). RS-1 enhances CRISPR/Cas9-and TALEN-mediated knock-in efficiency. Nature communications, 7. Pinder, J., Salsman, J., & Dellaire, G. (2015). Nuclear domain ‘knock-in’screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing. Nucleic acids research, gkv993. Jayathilaka, K., Sheridan, S. D., Bold, T. D., Bochenska, K., Logan, H. L., Weichselbaum, R. R., ... & Connell, P. P. (2008). A chemical compound that stimulates the human homologous recombination protein RAD51. Proceedings of the National Academy of Sciences, 105(41), 15848-15853. |