Rosiglitazone

Grouped product items
Size	Price	Qty
10mg	$35.00
50mg	$115.00

Catalog Number : 1227342

description

Rosiglitazone is an antidiabetic agent and a potent selective PPARγ agonist. It functions as an antidiabetic by binding to fat cell PPARγ receptors and inducing greater insulin sensitivity in the cells. It is reported to stimulate neuronal differentiation and proliferation. In angiogenic progenitor cells, Rosiglitazone promotes the differentiation of endothelial cells and inhibits smooth muscle differentiation.

Additional Information

Applications:	FA
Synonyms:	Avandia, Rosiglizole, rosiglitazona, BRL49653, Gaudil
Formulation:	Crystalline solid
Chemical Name:	5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Molecular Formula:	C₁₈H₁₉N₃O₃S
Molecular Weight:	357.4
CAS Number	122320-73-4
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Fryer, L. G., Parbu-Patel, A., & Carling, D. (2002). The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. Journal of Biological Chemistry, 277(28), 25226-25232. DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators. (2006). Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. The Lancet, 368(9541), 1096-1105. Wang, C. H., Ciliberti, N., Li, S. H., Szmitko, P. E., Weisel, R. D., Fedak, P. W., ... & Verma, S. (2004). Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage a new paradigm in glitazone pleiotropy.Circulation, 109(11), 1392-1400.