KRN 7000
Catalog Number : 1584771
description
KRN 7000 is a potent activator of NKT cells and CD1d ligand that was originally isolated from the murine sponge Agelas mauritianus. It exhibits immunostimulant and anti-tumor properties and is also reported to protect against LPS-induced shock.
Additional Information
Applications: | FA |
Synonyms: | KRN7000, alpha-GalCer, alpha-Galactosylceramide |
Formulation: | Crystalline solid |
Chemical Name: | N-[(2S,3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide |
Molecular Formula: | C50H99NO9 |
Molecular Weight: | 858.3 |
CAS Number | 158021-47-7 |
Purity: | ≥96% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Banchet-Cadeddu, A., Hénon, E., Dauchez, M., Renault, J. H., Monneaux, F., & Haudrechy, A. (2011). The stimulating adventure of KRN 7000. Organic & biomolecular chemistry, 9(9), 3080-3104. Kobayashi, E., Motoki, K., Uchida, T., Fukushima, H., & Koezuka, Y. (1995). KRN7000, a novel immunomodulator, and its antitumor activities. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 7(10-11), 529-534. Hayakawa, Y., Rovero, S., Forni, G., & Smyth, M. J. (2003). α-Galactosylceramide (KRN7000) suppression of chemical-and oncogene-dependent carcinogenesis. Proceedings of the National Academy of Sciences, 100(16), 9464-9469. |