Jasplakinolide

Grouped product items
SizePrice Qty
50ug
$195.00
100ug
$325.00
Catalog Number : 1022476

description

Jasplakinolide is a naturally occurring cyclic peptide that is a potent inducer of actin polymerization and was originally isolated from marine sponge Jaspis johnstoni. It is cell permeable and exhibits fungicidal and anti-proliferative activity.
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Additional Information

Applications:
FA
Synonyms:
Jaspamide, NSC 613009
Formulation:
Crystalline solid
Chemical Name:
(4R,7R,10S,13S,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
Molecular Formula:

C36H45BrN4O6

Molecular Weight:
709.7
CAS Number
102396-24-7
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Bubb, M. R., Senderowicz, A. M., Sausville, E. A., Duncan, K. L., & Korn, E. D. (1994). Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. Journal of Biological Chemistry269(21), 14869-14871.

Bubb, M. R., Spector, I., Beyer, B. B., & Fosen, K. M. (2000). Effects of jasplakinolide on the kinetics of actin polymerization an explanation for certain in vivo observations. Journal of Biological Chemistry275(7), 5163-5170.

Holzinger, A. (2001). Jasplakinolide. In Cytoskeleton Methods and Protocols (pp. 109-120). Humana Press.

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