GW 4064

Grouped product items
Size Price Qty
1mg
$30.00
10mg
$120.00
Catalog Number : 2783097

description

GW 4064 is a selective and potent agonist of the Farnesoid X receptor, a regulator of bile acid and lipid homeostasis. It does not react with the retinoic acid receptor at concentrations of up to 1uM.

Additional Information

Applications:
FA
Synonyms:
GW-4064, GW4064
Formulation:
Crystalline solid
Chemical Name:
3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid
Molecular Formula:

C28H22Cl3NO4

Molecular Weight:
542.8
CAS Number
278779-30-9
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Kuipers, F., Claudel, T., Sturm, E., & Staels, B. (2004). The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism. Reviews in Endocrine and Metabolic Disorders5(4), 319-326.

Dai, J., Wang, H., Shi, Y., Dong, Y., Zhang, Y., & Wang, J. (2011). Impact of bile acids on the growth of human cholangiocarcinoma via FXR. J Hematol Oncol4, 41.

Liu, Y., Binz, J., Numerick, M. J., Dennis, S., Luo, G., Desai, B., ... & Jones, S. A. (2003). Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis. The Journal of clinical investigation112(11), 1678-1687.

© BioGems International, Inc. All rights reserved.