GW 4064
Catalog Number : 2783097
description
GW 4064 is a selective and potent agonist of the Farnesoid X receptor, a regulator of bile acid and lipid homeostasis. It does not react with the retinoic acid receptor at concentrations of up to 1uM.
Additional Information
Applications:
|
FA
|
Synonyms:
|
GW-4064, GW4064
|
Formulation:
|
Crystalline solid
|
Chemical Name:
|
3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid
|
Molecular Formula:
|
C28H22Cl3NO4 |
Molecular Weight: |
542.8
|
CAS Number
|
278779-30-9
|
Purity:
|
≥95%
|
Storage Conditions:
|
Product should be kept at -20°C.
|
References:
|
Kuipers, F., Claudel, T., Sturm, E., & Staels, B. (2004). The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism. Reviews in Endocrine and Metabolic Disorders, 5(4), 319-326. Dai, J., Wang, H., Shi, Y., Dong, Y., Zhang, Y., & Wang, J. (2011). Impact of bile acids on the growth of human cholangiocarcinoma via FXR. J Hematol Oncol, 4, 41. Liu, Y., Binz, J., Numerick, M. J., Dennis, S., Luo, G., Desai, B., ... & Jones, S. A. (2003). Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis. The Journal of clinical investigation, 112(11), 1678-1687. |