G-1
Catalog Number : 8819813
description
G-1 is a selective and potent agonist against the GPR30 receptor, an estradiol binding receptor that contributes to both uterine and neurological responses. G-1 inhibits the production of lipopolysaccharide (LPS) induced cytokines such as IL-6 and TNF-alpha. It is also reported to block MCF-1 cell cycle progression at the G1 phase and display therapeutic effects in multiple sclerosis models.
Additional Information
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Applications:
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FA
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Synonyms:
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GPR30 Agonist, AC1MJFYZ, MLS001242405
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Formulation:
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Crystalline solid
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Chemical Name:
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1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone
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Molecular Formula:
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C21H18BrNO3 |
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Molecular Weight: |
412.3
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CAS Number
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881639-98-1
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Bologa, C. G., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., ... & Prossnitz, E. R. (2006). Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature chemical biology,2(4), 207-212. Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks-Miller, M., Mahmoudi, M., ... & Horuk, R. (2009). Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. Journal of neuroimmunology, 214(1), 67-77. Kumar, R., Balhuizen, A., Amisten, S., Lundquist, I., & Salehi, A. (2011). Insulinotropic and antidiabetic effects of 17β-estradiol and the GPR30 agonist G-1 on human pancreatic islets. Endocrinology, 152(7), 2568-2579. |