G-1

Grouped product items
Size Price Qty
10mg
$165.00
25mg
$380.00
Catalog Number : 8819813

description

G-1 is a selective and potent agonist against the GPR30 receptor, an estradiol binding receptor that contributes to both uterine and neurological responses. G-1 inhibits the production of lipopolysaccharide (LPS) induced cytokines such as IL-6 and TNF-alpha. It is also reported to block MCF-1 cell cycle progression at the G1 phase and display therapeutic effects in multiple sclerosis models.

Additional Information

Applications:
FA
Synonyms:
GPR30 Agonist, AC1MJFYZ, MLS001242405
Formulation:
Crystalline solid
Chemical Name:
1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone
Molecular Formula:

C21H18BrNO3

Molecular Weight:
412.3
CAS Number
881639-98-1
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Bologa, C. G., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., ... & Prossnitz, E. R. (2006). Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature chemical biology,2(4), 207-212.

Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks-Miller, M., Mahmoudi, M., ... & Horuk, R. (2009). Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. Journal of neuroimmunology214(1), 67-77.

Kumar, R., Balhuizen, A., Amisten, S., Lundquist, I., & Salehi, A. (2011). Insulinotropic and antidiabetic effects of 17β-estradiol and the GPR30 agonist G-1 on human pancreatic islets. Endocrinology152(7), 2568-2579.

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