AICAR

Grouped product items
Size	Price	Qty
50mg	$50.00
100mg	$90.00

Catalog Number : 2626926

description

AICAR is a cell-permeable adenosine analog that is a selective activator of AMP-activated protein kinase (AMPK) in adipocytes and hepatocytes. The AMPK is a metabolic regulator that inhibits anabolic processes and is active when energy availability is reduced. AICAR is reported to promote osteogenic differentiation of mesenchymal stem cells in vitro and astroglial differentiation in neural stem cells.

Additional Information

Applications:	FA
Synonyms:	Acadesine, AICA ribonucleoside, aminoimidazole carboxamide ribonucleoside, ARA100,1-ribosyl-4-carboxamido-5-aminoimidazole
Formulation:	Crystalline solid
Chemical Name:	5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
Molecular Formula:	C₉H₁₄N₄O₅
Molecular Weight:	258.2
CAS Number	2627-69-2
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., & Beri, R. K. (1994). Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS letters, 353(1), 33-36. Young, M. E., Radda, G. K., & Leighton, B. (1996). Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR—an activator of AMP-activated protein kinase. FEBS letters, 382(1), 43-47. Iglesias, M. A., Ye, J. M., Frangioudakis, G., Saha, A. K., Tomas, E., Ruderman, N. B., ... & Kraegen, E. W. (2002). AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes, 51(10), 2886-2894.