9-cis-Retinoic acid
Catalog Number : 5300380
description
9-cis-Retinoic acid is a potent activator of all isoforms of retinoic acid receptor and the retinoid X receptor, which act as transcription factors that regulate the growth and differentiation of normal and malignant cells.. It is reported to promote oligodendrocyte precursor cell differentiation and myelination and to also inhibit the synthesis of fatty acids and sterols in hepatocytes.
Additional Information
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Applications:
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FA
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Synonyms:
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Alitretinoin, 9-cis-Tretinoin, Panretin
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Formulation:
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Crystalline solid
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Chemical Name:
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(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
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Molecular Formula:
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C20H28O2 |
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Molecular Weight: |
300.4
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CAS Number
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5300-03-8
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992). 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell, 68(2), 397-406. Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., ... & Grippo, J. F. (1992). 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. MacDonald, P. N., Dowd, D. R., Nakajima, S., Galligan, M. A., Reeder, M. C., Haussler, C. A., ... & Haussler, M. R. (1993). Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1, 25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene. Molecular and cellular biology, 13(9), 5907-5917. |