8-Bromo-cAMP
Catalog Number : 2354843
description
8-Bromo-cAMP is a cell-permeable brominated derivative of cAMP that is longer lasting due to a higher resistance to cyclic AMP phosphodiesterase. cAMP activates protein kinases, used for intracellular signal transduction, and regulates the function of ion channels. 8-Bromo-cAMP is reported to enhance the induction of pluripotency in human fibroblast cells and protects neutrophils against TNF-α-induced apoptosis.
Additional Information
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Applications:
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FA
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Synonyms:
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8 Bromo cAMP; 8 Bromo Cyclic Adenosine Monophosphate; 8 Bromo Cyclic AMP; 8 Bromo Cyclic Adenosine Monophosphate; Br Cycl AMP
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Formulation:
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Crystalline solid
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Chemical Name:
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(4aR,6R,7R,7aS)-6-(6-amino-8-bromopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
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Molecular Formula:
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C10H11BrN5PO6 |
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Molecular Weight: |
408.1
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CAS Number
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23583-48-4
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Rydel, R. E., & Greene, L. A. (1988). cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proceedings of the National Academy of Sciences, 85(4), 1257-1261. Ringler, G. E., Lee-Chuan, K., Miller, W. L., & Strauss, J. F. (1989). Effects of 8-bromo-cAMP on expression of endocrine functions by cultured human trophoblast cells. Regulation of specific mRNAs. Molecular and cellular endocrinology, 61(1), 13-21. Wang, Y., & Adjaye, J. (2011). A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Reviews and Reports, 7(2), 331-341. |