1-EBIO
Catalog Number : 1004515
description
1-EBIO is an epithelial Ca2+-activated K+ and CFTR channel activator. It is reported to enhance the differentiation of embryonic stem cells into cardiomyocytes.
Additional Information
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Applications:
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FA
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Synonyms:
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1-ethyl-2-benzimidazolinone, 1-Ethylbenzimidazolinone, 1-EB10
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Formulation:
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Crystalline solid
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Chemical Name:
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3-ethyl-1H-benzimidazol-2-one
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Molecular Formula:
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C9H10N2O |
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Molecular Weight: |
162.2
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CAS Number
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10045-45-1
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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1.Anderson, N. J., Slough, S., & Watson, W. P. (2006). In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. European journal of pharmacology, 546(1-3), 48-53.
2.Walker, S. D., Doras, K. A., Ings, N. T., Crane, G. J., & Garland, C. J. (2001). Activation of endothelial cell IKCa with 1‐ethyl‐2‐benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery. British journal of pharmacology, 134(7), 1548-1554.
3.Müller, M., Stockmann, M., Malan, D., Wolheim, A., Tischendorf, M., Linta, L., ... & Wobus, A. M. (2012). Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men. Stem Cell Reviews and Reports, 8(3), 720-740.
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