4-Hydroxytamoxifen

Grouped product items
SizePrice Qty
10mg
$65.00
50mg
$240.00
Catalog Number : 6833585

description

Tamoxifen is a modulator of the of the estrogen receptor, with tissue specific agonistic and antagonistic effects. 4-hydroxy Tamoxifen is the active metabolite of tamoxifen that is also generated in the liver by the CYP2D6 enzyme. It exhibits a greater potency than the parent compound and is reported to be cytostatic and prevent cancerous cells from dividing.
product image

Additional Information

Applications:
FA
Synonyms:
afimoxifene, 4OH-tamoxifen, 4-monohydroxytamoxifen
Formulation:
Crystalline solid
Chemical Name:
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
Molecular Formula:

C26H29NO2

Molecular Weight:
387.5
CAS Number
68392-35-8
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Jordan, V. C., COLLINS, M. M., ROWSBY, L., & Prestwich, G. (1977). A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. Journal of Endocrinology75(2), 305-316.

Seeger, H., Huober, J., Wallwiener, D., & Mueck, A. O. (2004). Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifen. Hormone and metabolic research= Hormon-und Stoffwechselforschung= Hormones et metabolisme36(5), 277-280.

Desta, Z., Ward, B. A., Soukhova, N. V., & Flockhart, D. A. (2004). Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. Journal of Pharmacology and Experimental Therapeutics310(3), 1062-1075.

© BioGems International, Inc. All rights reserved.