3-Deazaneplanocin A
description
Additional Information
Applications:
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FA
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Synonyms:
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DZNep, NSC 617989
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Formulation:
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Crystalline solid
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Chemical Name:
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(1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
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Molecular Formula:
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C12H14N4O3 |
Molecular Weight: |
262.3
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CAS Number
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102052-95-9
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Purity:
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≥97%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Fiskus, W., Wang, Y., Sreekumar, A., Buckley, K. M., Shi, H., Jillella, A., ... & Bhalla, K. N. (2009). Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood, 114(13), 2733-2743. Glazer, R. I., Hartman, K. D., Knode, M. C., Richard, M. M., Chiang, P. K., Tseng, C. K., & Marquez, V. E. (1986). 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochemical and biophysical research communications, 135(2), 688-694. Bray, M., Raymond, J. L., Geisbert, T., & Baker, R. O. (2002). 3-Deazaneplanocin A induces massively increased interferon-α production in Ebola virus-infected mice. Antiviral research, 55(1), 151-159. |