SB 431542
description
Additional Information
Applications: | FA |
Synonyms: | SB-431542, CHEMBL440084, 3tzm, GTPL8216, FHYUGAJXYORMHI-UHFFFAOYSA-N |
Formulation: | Crystalline solid |
Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide |
Molecular Formula: | C22H16N4O3 |
Molecular Weight: | 384.4 |
CAS Number | 301836-41-9 |
Purity: | ≥98% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., ... & Hill, C. S. (2002). SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Molecular pharmacology, 62(1), 65-74. Laping, N. J., Grygielko, E., Mathur, A., Butter, S., Bomberger, J., Tweed, C., ... & Olson, B. A. (2002). Inhibition of transforming growth factor (TGF)-β1–induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Molecular pharmacology, 62(1), 58-64. Halder, S. K., Beauchamp, R. D., & Datta, P. K. (2005). A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia, 7(5), 509-521. |